Scientific training is essential to achieve the greatest possible success in assisted reproduction treatments. Without education and research it would be impossible to imagine all the advances that have been made in this field. Therefore, today we would like to proudly share a new milestone of our Ovolearning professional team: the publication of a study in the Journal of Assisted Reproduction and Genetics (JARG) and soon to be indexed in Pubmed, the most recognised medical database in the world.
The aim of this multicentre study demonstrates the efficacy of the Universal Warming Protocol (UWP) using different devitrification media in donor egg that were previously vitrified in a single egg bank.
This reason raises the importance and relevance of the research and study of Ovolearning’s expert embryologists. This revealing multicentre study with international impact serves to provide more information to the field of assisted reproduction.
What does the Ovolearning study consist of?
This multicentre study is to demonstrate the efficacy of the Universal Warming Protocol (UWP) using different means of devitrification in donor eggs that were previously vitrified in a single egg bank. In this case, Ovobank.
For this purpose, 2172 metaphase II eggs were used. All of them were vitrified in Ovobank (Spain). These eggs were devitrified in three different centres: with Kitazato medium (Japan), with Irvine medium (USA) and with RapidWarm medium (Sweden). The study parameters were survival rate, fertilisation rate, cleavage rate, blastulation rate and pregnancy rate confirmed by biochemical test; embryo transfer at D+3 and D+5; and clinical pregnancy rate.
Key findings and conclusions about UWP for the devitrification eggs
The results of the study showed little difference between the study parameters used. Therefore, it is concluded that it does not matter which means of devitrification for donor eggs is used, and it may be a different means than the one used to vitrify the eggs.
*At Ovolearning we will continue to train embryologists to the highest standards and contribute to scientific knowledge. If you want to know more about our studies, training or research work, visit www.ovolearning.com or contact us directly.
What does this study contribute to the field of embryology/assisted reproduction?
An idea of the advantage of using a UWP for devitrification is that it simplifies the exchange of vitrified oocytes between IVF centres in different countries. This overcomes potential commercial or availability differences that may affect clinical practice. Assisted Reproduction centres can select the devitrification media that best suits their needs, regardless of the commercial brand used during the vitrification process and, logically, depending on the cost, stock and reliability of the brand or distributor.
What does it mean to publish in Journal of Assisted Reproduction and Genetics?
The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic and epigenetic discoveries that advance the understanding of the biology and underlying mechanisms from gametogenesis to the health of offspring. Particular emphasis is placed on the practice and evolution of assisted reproductive technologies (ART) with reference to the diagnosis and management of diseases affecting fertility.
Journal that during 2023 has been among the top 25 (First Quartile, Q1) scientific journals in Reproductive Medicine. With an Impact Index of 3.2 according to JRC (Journal Citation Reports).
What about indexing in PubMed?
PubMed is a database of the US National Library of Medicine that facilitates the search for biomedical and life sciences literature free of charge. In fact, it is the most widely used search engine by health professionals worldwide. All the studies in this library are thoroughly reviewed by professional experts before being published.
Quotation from the study published in the Journal of Assisted Reproduction and Genetics
Troncoso-Perez, P., Gonzalez-Navas, C., Coccia, M.E. et al. Application of a single “Universal warming protocol” for vitrified donor oocytes: A multicenter study. J Assist Reprod Genet (2025). https://doi.org/10.1007/s10815-025-03423-7
